This work may not be copied, distributed, displayed, published, reproduced, transmitted, modified, posted, sold, licensed, or used for commercial purposes. By downloading this file, you are agreeing to the publisher’s Terms & Conditions.

Original Research

Clozapine and Obsessions in Patients With Recent-Onset Schizophrenia and Other Psychotic Disorders.

Lieuwe de Haan, Don H. Linszen, and Rob Gorsira

Published: June 30, 1999

Article Abstract

Background: The increase or emergence of obsessions was compared in young patients with recent-onset schizophrenia or other psychotic disorders taking clozapine and other antipsychotic drugs.

Method: We conducted a retrospective cohort study. Subjects were 121 consecutively admitted patients diagnosed with DSM-III-R schizophrenia, schizoaffective disorder, schizophreniform disorder, or psychotic disorder not otherwise specified. Obsessions were diagnosed according to DSM-IV criteria.

Results: More clozapine-treated subjects (20.6%) than subjects treated with other antipsychotic drugs (1.3%) experienced an emergence or increase of obsessions (p < .01).

Conclusion: Use of clozapine is associated with the emergence or increase of obsessions in early-phase schizophrenia.

Volume: 60

Quick Links:

Continue Reading…

Subscribe to read the entire article


Buy this Article as a PDF