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Letter to the Editor

Absence of Cardiac Side Effects During Treatment of Schizophrenia With Risperidone in a Patient With Wolff-Parkinson-White Syndrome

Fabrice Bon, MD; Eric Louis Constant, MD, PhD; Peter Goethals, MD; and Daniel Neu, MD

Published: June 15, 2007

Article Abstract

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Sir: Excessive prolongation of the QT interval can predisposeto a peculiar ventricular arrhythmia called torsade depointes, or sudden cardiac death. QT prolongation has beenfound to occur with some older conventional and newer atypicalantipsychotics.1 Nevertheless, the recent literature suggests thatatypical antipsychotics are not associated with torsade depointes except in the case of a concomitant risk factor (e.g.,polypharmacy, overdose, restraint, substance misuse, electrolyteimbalance).1,2

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