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To the Editor: Treatment-resistant depression is common, challenging, and difficult to treat. In this case report, we discuss the role of using multiple dopaminergic medications to achieve remission of depression. To our knowledge, this is the first case report on the use of combination therapy (clomipramine, dextroamphetamine, pramipexole, and aripiprazole) for electroconvulsive therapy-resistant unipolar depression.
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