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To the Editor: Olanzapine and clozapine are structurally similar dibenzodiazepines with some overlapping adverse effects. However, while drug-induced fever is considered a frequent side effect associated with clozapine, it has rarely been described with olanzapine. Current hypotheses conjecture an induction of fever due to dopaminergic antagonism that would elevate the hypothalamic thermoregulatory set point and the production of endogenous pyrogens, with consequent release of local cytokines.
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