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Sir: Quetiapine fumarate is a dibenzothiazepinederivativeantipsychotic with combined antagonism atdopamine (D1, D2) and serotonin type 1 and type 2 (5-HT1A,5-HT2A, 5-HT2C) receptors. Additionally, quetiapine antagonizesα1– and α2-adrenergic andhistamine H1 receptors.Protean binding at the above receptors explains thecommon side effects, which include hypersomnolence,hypotension, headache, weight gain, and gastrointestinaldisturbance.
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