Clozapine-Valproate Adverse Drug Reactions and the Need for a Clozapine Rechallenge Case File

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To the Editor: Nielsen and colleagues recently commented on our work regarding clozapine-induced acute renal failure (CIARF). These comments were extremely informative and generate further thought on the issue of clozapine rechallenge. The authors state: "It is highly important that any patient who experienced a serious/potentially life threatening ADR [adverse drug reaction] with clozapine who is later rechallenged is reflected in the literature, so that we can learn more about under which circumstances clozapine rechallenge is or is not safe."