Letter to the Editor August 9, 2018

Trimethoprim-Sulfamethoxazole-Induced Exacerbation of Anxiety and Depression

; ;

Prim Care Companion CNS Disord 2018;20(4):17l02224

Article Abstract

Because this piece does not have an abstract, we have provided for your benefit the first 3 sentences of the full text.

To the Editor: Trimethoprim-sulfamethoxazole is a broad-spectrum antibiotic prescribed for the treatment of uncomplicated infections. It is an irreversible inhibitor of dihydrofolate reductase, leading to a reduction in the production of folic acid. The combination of trimethoprim and sulfamethoxazole works as a bactericidal antibiotic due to its synergistic effect.