The Journal of
Clinical Psychiatry

Volume 86 • 2025 • 4

Meta-Analysis

Comparing Prevalence of Burnout in Psychiatric Doctors Before and After the COVID-19 Pandemic: A Systematic Review and Meta-Analysis

J Clin Psychiatry 2025;86(4):24r15697

Kathryn L. Johnson, MP; Michael S. Gordon, MD; Hannah G. Gordon, MD

Narrative Review

Failing Public Health Again? Analytical Review of Depression and Suicidality From Finasteride

J Clin Psychiatry 2025;86(4):25nr15862

Mayer Brezis, MD, MPH

Original Research

The Emory Treatment Resistance Interview for PTSD—Short Version (E-TRIP-S)

J Clin Psychiatry 2025;86(4):25m15956

Boadie W. Dunlop, MD; Nathaniel L. Phillips, MS; Barbara O. Rothbaum, PhD

Original Research

Identifying Factors Linked to a Higher Prevalence of Posttraumatic Stress Disorder Among Younger US Military Veterans

J Clin Psychiatry 2025;86(4):25m15939

Jordan R. Hathorn, PA; Ian C. Fischer, PhD; Peter J. Na, MD, MPH; Robert H. Pietrzak, PhD, MPH

Original Research

Aripiprazole or Bupropion Augmentation Versus Switching to Bupropion in Treatment-Resistant Depression: A Risk-Benefit Analysis

J Clin Psychiatry 2025;86(4):25m15863

William U. Meyerson, MD, PhD; Eric L. Ross, MD; Chris J. Kennedy, PhD, MPA; Rick H. Hoyle, PhD; Jagpreet Chhatwal, PhD; Philip S. Wang, MD, DrPH; Jordan W. Smoller, MD, ScD

Original Research

Effects of Interpersonal and Social Rhythm Therapy on Suicidal Ideation in Adults With Bipolar II Depression

J Clin Psychiatry 2025;86(4):24m15768

Bridget C. Bailey, PhD, LICSW; Theresa J. Early, PhD; Kathryn E. Williams-Sites, MSW; Bailey Dyson, BA; Holly A. Swartz, MD

Original Research

Ketamine Reduces Suicidality-Associated Emergency Department Utilization in Patients With Treatment-Resistant Depression: A 6-Month Mirror-Image Study

J Clin Psychiatry 2025;86(4):25m15941

Liliana Patarroyo-Rodriguez, MD, MS; Vanessa K. Pazdernik, MS; Jennifer L. Vande Voort, MD; Simon Kung, MD; Mark A. Frye, MD; Balwinder Singh, MD, MS

Original Research

Symptom Network Analysis of Attention-Deficit/Hyperactivity Disorder and Emotional Symptoms in Adults: Results From the National Epidemiologic Survey on Alcohol and Related Conditions (NESARC)

J Clin Psychiatry 2025;86(4):24m15287

Christophe Gauld, MD, PhD; Sarah Tebeka, MD, PhD; Diane Purper-Ouakil, MD, PhD; Pierre Fourneret, MD, PhD; Hugo Peyre, MD, PhD; Yann Le Strat, MD, PhD

Original Research

Esmethadone (REL-1017) in Patients With Major Depressive Disorder and Antidepressant Tachyphylaxis: An Exploratory Post Hoc Analysis From a Phase 3 Randomized Controlled Trial

J Clin Psychiatry 2025;86(4):24m15748

Clotilde Guidetti, MD; George I. Papakostas, MD; Luca Pani, MD; Sara De Martin, PhD; Giulia Serra, MD; Massimo Apicella, MD; Cornelia Kröger, PhD; Paggard Champasa, PhD; Stefano Comai, PhD; Andrea Mattarei, PhD; Franco Folli, MD; Marco Pappagallo, MD; Paolo L. Manfredi, MD; Maurizio Fava, MD

Original Research

Depression at 2 Months Postpartum: Results From the French National Perinatal Survey

J Clin Psychiatry 2025;86(4):25m15818

Alexandra Doncarli, PhD; Virginie Demiguel, MSc; Camille Le Ray, MD, PhD; Catherine Deneux-Tharaux, MD, PhD; Elodie Lebreton, PhD; Gisèle Apter, MD, PhD; Julie Boudet-Berquier, BSM, PhD; Anne Alice Chantry, BSM, PhD; Catherine Crenn-Hebert, MD, PhD; Marie-Noëlle Vacheron, MD, PhD; Nolwenn Regnault, DMD, PhD; Sarah Tebeka, MD, PhD

Original Research

Lumateperone as Adjunctive Therapy in Patients With Major Depressive Disorder: Results From a Randomized, Double-Blind, Phase 3 Trial

J Clin Psychiatry 2025;86(4):25m15848

Suresh Durgam, MD; Willie R. Earley, MD; Susan G. Kozauer, MD; Changzheng Chen, PhD; Hassan Lakkis, PhD; Roger S. McIntyre, MD; Stephen Stahl, MD, PhD

<em>N</em>-Acetylcysteine for the Treatment of Co-Occurring Posttraumatic Stress Disorder and Alcohol Use Disorder: A Double-Blind, Randomized Controlled Trial

Original Research

N-Acetylcysteine for the Treatment of Co-Occurring Posttraumatic Stress Disorder and Alcohol Use Disorder: A Double-Blind, Randomized Controlled Trial

J Clin Psychiatry 2025;86(4):25m15803

Sudie E. Back, PhD; Kevin Gray, MD; Amber M. Jarnecke, PhD; Tanya C. Saraiya, PhD; Elizabeth J. Santa Ana, PhD; Therese Killeen, PhD; Jane E. Joseph, PhD; James J. Prisciandaro, PhD; Delisa G. Brown, PhD; Paul J. Nietert, PhD; Tracy Stecker, PhD; Alex Rothbaum, PhD; Jennifer L. Jones, MD; Julianne C. Flanagan, PhD; Kathleen T. Brady, MD, PhD

Original Research

Five-Year Outcomes of First Suicide Attempts: Insights on Lethality, Recurrence, and Mortality

J Clin Psychiatry 2025;86(4):24m15754

Eugènia Nicolau-Subires, MD; Maria Irigoyen-Otiñano, MD, PhD; Laura Arenas-Pijoan, MD; Marina Adrados-Pérez, MD; Carla Albert-Porcar, MD; Lucía Ibarra-Pertusa, MD; María Mur-Laín, MD, PhD; Jorge Lopez-Castroman, MD, PhD; Vicent Llorca-Bofí, MD

Original Research

A Year in the Shadow of Terror: Longitudinal Effects of the October 7, 2023, Terrorist Attack on PTSD, Depression, Anxiety, and Suicidal Ideation Across Distinct Exposure Groups

J Clin Psychiatry. 2025;86(4):25m15970

Yossi Levi-Belz, PhD; Doron Amsalem, MD; Yoav Groweiss, PhD; Carmel Blank, PhD; Iris Shachar-Lavie, PhD; Yuval Neria, PhD

Original Research

Comparing the Cognitive Effects of Repeated Intravenous Ketamine and Electroconvulsive Therapy in Patients With Treatment-Resistant Depression: A Secondary Analysis of the ELEKT-D Trial

J Clin Psychiatry 2025;86(4):25m15781

Kristina T. Kumpf, MA; Samuel T. Wilkinson, MD; Bo Hu, PhD; Ruoying Chen, PhD; Kamini Krishnan, PhD; Shinjon Chakrabarti, BS; Taeho Greg Rhee, PhD; Tiffany Grezmak, MA; Sanjay J. Mathew, MD; Gerard Sanacora, MD, PhD; James W. Murrough, MD, PhD; Fernando S. Goes, MD; Katherine A. Collins, PhD; LCSW; Brian S. Barnett, MD; Amit Anand, MD

Original Research

New Onset Mental Health Diagnosis and Emergent Service Utilization Associated With Bariatric Surgery

J Clin Psychiatry 2025;86(4):25m15806

Mark M. Halim, MD; AnMarie Nguyen, PhD; Karen J. Coleman, PhD; Hilary A. Bennett, MD

Original Research

Comparative Effects of Repeated Ketamine Infusion Versus Intranasal Esketamine in Patients With Treatment-Resistant Depression: A Retrospective Chart Review

J Clin Psychiatry. 2025;86(4):25m15789

Robert Meisner, MD; Shuang Li, MD, PhD; Brian Boyle, MD; Violeta Valdivia, MD; Amanda Sedgewick, DO; Danika Dai, BS; Courtney Miller, BA, RN; Paula Bolton, MS, CNP; Steve Seiner, MD

Original Research

Relationships Between Body Composition and Mental Health During Pregnancy Are Moderated by Physical Activity and Diet

J Clin Psychiatry. 2025;86(4):25m15822

Yali Huang, PhD; Chary Akmyradov, PhD; Matthew T. Keene, BS; Sabrina L. Chambers, BS; Trevor D. Durey, BS; Xiaoxu Na, MS; Jayne Bellando, PhD; Xiawei Ou, PhD

Commentary

The Emerging Science of Clinimetrics: Implications for Clinical Psychiatry

J Clin Psychiatry 2025;86(4):25com16124

Jenny Guidi, PsyD, PhD

Commentary

Prioritizing Mental Health to Optimize Perinatal, Fetal, and Neonatal Outcomes

J Clin Psychiatry 2025;86(4):25com16100

Kay Roussos-Ross, MD; Tiffany A. Moore Simas, MD, MPH, MEd, MHCM; M. Camille Hoffman, MD, MSc; Emily S Miller, MD, MPH

Commentary

Why Getting Major Depression Right Matters—For Mothers, Babies, and All of Us

J Clin Psychiatry 2025;86(4):25com16092

Jennifer L. Payne, MD

Commentary

Beyond the Boxed Warning: A Call for Regulation of Psychiatry’s Most Teratogenic Drug

J Clin Psychiatry 2025;86(4):25com16026

Mariella Suleiman, MD; David F. Silver, MD; Ariadna Forray, MD; Nichole Goodsmith, MD, PhD

Commentary

Ketamine and Esketamine: Is There a Meaningful Clinical Difference?

J Clin Psychiatry 2025;86(4):25com16003

Samuel T. Wilkinson, MD; Taeho Greg Rhee, PhD, FACE

Commentary

Practitioners Providing Care for Persons With Severe Mental Disorders Should Routinely Screen for Metabolic Dysfunction–Associated Steatotic Liver Disease

J Clin Psychiatry. 2025;86(4):25com16021

Roger S. McIntyre, MD, FRCPC; Gia Han Le, HBSc

Clinical and Practical Psychopharmacology

Dosing Patients With Oral Iron Supplements: Practical Guidance

J Clin Psychiatry 2025;86(4):25f16139

Chittaranjan Andrade, MD

Clinical and Practical Psychopharmacology

Ketamine-Associated Uropathy During Therapeutic and Nontherapeutic Use: Prevalence, Clinical Features, Mechanisms, and Strategies for Risk Reduction

J Clin Psychiatry. 2025;86(4):25f16083

Chittaranjan Andrade, MD

ASCP Corner

What Is Meant by the Term “Deprescribing,” and Does It Belong in Our Lexicon?

J Clin Psychiatry 2025;86(4):25ac15936

Joseph F. Goldberg, MD; Holly A. Swartz, MD; Rajnish Mago, MD; Roger S. McIntyre, MD; Gin S. Malhi, MD; Joshua D. Rosenblat, MD; Marlene P. Freeman, MD; Eduard Vieta, MD; Michael E. Thase, MD; Mauricio Tohen, MD; Leslie Citrome, MD, MPH

Brief Report

Nonmedical Use and Substance Use Disorder Symptoms Among US Adults Coprescribed Opioids and Benzodiazepines

J Clin Psychiatry 2025;86(4):25br15937

Emily Pasman, PhD; Phil Veliz, PhD; Elizabeth Hoffman, MD; Rebecca Evans-Polce, PhD; Ty S. Schepis, PhD; Megan E. Patrick, PhD; Joshua Truchan, BSN; Timothy E. Wilens, MD; John Jardine, MS; Vita V. McCabe, MD; Sean Esteban McCabe, PhD

Letter to the Editor

Reasons for Maintaining the Classification of Esmethadone as an Investigational Uncompetitive NMDAR Antagonist Rapid Antidepressant: Reply to Ferré and Michaelides

J Clin Psychiatry 2025;86(4):25lr15973a

Sara De Martin, PhD; Stefano Comai, PhD; Andrea Mattarei, PhD; Thomas R. Kosten, MD; Frank J. Vocci, PhD; Charles W. Gorodetzky, MD, PhD; Marco Pappagallo, MD; Paolo L. Manfredi, MD

Letter to the Editor

Toward Consensus in Psychedelic-Assisted Therapy: The Critical Role of Psychotherapeutic Support

J Clin Psychiatry 2025;86(4):25lr15978

Vania Modesto-Lowe, MD, MPH; Deanna Sgambato, DMS, MHS; PA-C Margaret Chaplin, MD

Letter to the Editor

Psychedelic Therapies: One Drug, Multiple Treatments: Reply to Modesto-Lowe et al

J Clin Psychiatry 2025;86(4):25lr15978a

David A. Bender, MD; Sandeep M. Nayak, MD; Joshua S. Siegel, MD, PhD; David J. Hellerstein, MD; Baris C. Ercal, MD, PhD; Eric J. Lenze, MD

Misleading Labeling of <em>S</em>-Methadone as a Novel <em>N</em>-Methyl-D-Aspartate Receptor Antagonist

Letter to the Editor

Misleading Labeling of S-Methadone as a Novel N-Methyl-D-Aspartate Receptor Antagonist

J Clin Psychiatry 2025;86(4):25lr15973

Sergi Ferré, MD, PhD; Michael Michaelides, PhD

Volume 86 • 2025 • 4

Meta-Analysis

Comparing Prevalence of Burnout in Psychiatric Doctors Before and After the COVID-19 Pandemic: A Systematic Review and Meta-Analysis

Narrative Review

Failing Public Health Again? Analytical Review of Depression and Suicidality From Finasteride

Original Research

The Emory Treatment Resistance Interview for PTSD—Short Version (E-TRIP-S)

Identifying Factors Linked to a Higher Prevalence of Posttraumatic Stress Disorder Among Younger US Military Veterans

Aripiprazole or Bupropion Augmentation Versus Switching to Bupropion in Treatment-Resistant Depression: A Risk-Benefit Analysis

Effects of Interpersonal and Social Rhythm Therapy on Suicidal Ideation in Adults With Bipolar II Depression

Ketamine Reduces Suicidality-Associated Emergency Department Utilization in Patients With Treatment-Resistant Depression: A 6-Month Mirror-Image Study

Symptom Network Analysis of Attention-Deficit/Hyperactivity Disorder and Emotional Symptoms in Adults: Results From the National Epidemiologic Survey on Alcohol and Related Conditions (NESARC)

Esmethadone (REL-1017) in Patients With Major Depressive Disorder and Antidepressant Tachyphylaxis: An Exploratory Post Hoc Analysis From a Phase 3 Randomized Controlled Trial

Depression at 2 Months Postpartum: Results From the French National Perinatal Survey

Lumateperone as Adjunctive Therapy in Patients With Major Depressive Disorder: Results From a Randomized, Double-Blind, Phase 3 Trial

N-Acetylcysteine for the Treatment of Co-Occurring Posttraumatic Stress Disorder and Alcohol Use Disorder: A Double-Blind, Randomized Controlled Trial

Five-Year Outcomes of First Suicide Attempts: Insights on Lethality, Recurrence, and Mortality

A Year in the Shadow of Terror: Longitudinal Effects of the October 7, 2023, Terrorist Attack on PTSD, Depression, Anxiety, and Suicidal Ideation Across Distinct Exposure Groups

Comparing the Cognitive Effects of Repeated Intravenous Ketamine and Electroconvulsive Therapy in Patients With Treatment-Resistant Depression: A Secondary Analysis of the ELEKT-D Trial

New Onset Mental Health Diagnosis and Emergent Service Utilization Associated With Bariatric Surgery

Comparative Effects of Repeated Ketamine Infusion Versus Intranasal Esketamine in Patients With Treatment-Resistant Depression: A Retrospective Chart Review

Relationships Between Body Composition and Mental Health During Pregnancy Are Moderated by Physical Activity and Diet

Commentary

The Emerging Science of Clinimetrics: Implications for Clinical Psychiatry

Prioritizing Mental Health to Optimize Perinatal, Fetal, and Neonatal Outcomes

Why Getting Major Depression Right Matters—For Mothers, Babies, and All of Us

Beyond the Boxed Warning: A Call for Regulation of Psychiatry’s Most Teratogenic Drug

Ketamine and Esketamine: Is There a Meaningful Clinical Difference?

Practitioners Providing Care for Persons With Severe Mental Disorders Should Routinely Screen for Metabolic Dysfunction–Associated Steatotic Liver Disease

Clinical and Practical Psychopharmacology

Dosing Patients With Oral Iron Supplements: Practical Guidance

Ketamine-Associated Uropathy During Therapeutic and Nontherapeutic Use: Prevalence, Clinical Features, Mechanisms, and Strategies for Risk Reduction

ASCP Corner

What Is Meant by the Term “Deprescribing,” and Does It Belong in Our Lexicon?

Brief Report

Nonmedical Use and Substance Use Disorder Symptoms Among US Adults Coprescribed Opioids and Benzodiazepines

Letter to the Editor

Reasons for Maintaining the Classification of Esmethadone as an Investigational Uncompetitive NMDAR Antagonist Rapid Antidepressant: Reply to Ferré and Michaelides

Toward Consensus in Psychedelic-Assisted Therapy: The Critical Role of Psychotherapeutic Support

Psychedelic Therapies: One Drug, Multiple Treatments: Reply to Modesto-Lowe et al

Misleading Labeling of S-Methadone as a Novel N-Methyl-D-Aspartate Receptor Antagonist

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