The Journal of
Clinical Psychiatry

Volume 86 • 2025 • 4

Original Research

New Onset Mental Health Diagnosis and Emergent Service Utilization Associated With Bariatric Surgery

J Clin Psychiatry 2025;86(4):25m15806

Mark M. Halim, MD; AnMarie Nguyen, PhD; Karen J. Coleman, PhD; Hilary A. Bennett, MD

Original Research

Identifying Factors Linked to a Higher Prevalence of Posttraumatic Stress Disorder Among Younger US Military Veterans

J Clin Psychiatry 2025;86(4):25m15939

Jordan R. Hathorn, PA; Ian C. Fischer, PhD; Peter J. Na, MD, MPH; Robert H. Pietrzak, PhD, MPH

Original Research

Ketamine Reduces Suicidality-Associated Emergency Department Utilization in Patients With Treatment-Resistant Depression: A 6-Month Mirror-Image Study

J Clin Psychiatry 2025;86(4):25m15941

Liliana Patarroyo-Rodriguez, MD, MS; Vanessa K. Pazdernik, MS; Jennifer L. Vande Voort, MD; Simon Kung, MD; Mark A. Frye, MD; Balwinder Singh, MD, MS

Original Research

Relationships Between Body Composition and Mental Health During Pregnancy Are Moderated by Physical Activity and Diet

J Clin Psychiatry. 2025;86(4):25m15822

Yali Huang, PhD; Chary Akmyradov, PhD; Matthew T. Keene, BS; Sabrina L. Chambers, BS; Trevor D. Durey, BS; Xiaoxu Na, MS; Jayne Bellando, PhD; Xiawei Ou, PhD

Original Research

Comparing the Cognitive Effects of Repeated Intravenous Ketamine and Electroconvulsive Therapy in Patients With Treatment-Resistant Depression: A Secondary Analysis of the ELEKT-D Trial

J Clin Psychiatry 2025;86(4):25m15781

Kristina T. Kumpf, MA; Samuel T. Wilkinson, MD; Bo Hu, PhD; Ruoying Chen, PhD; Kamini Krishnan, PhD; Shinjon Chakrabarti, BS; Taeho Greg Rhee, PhD; Tiffany Grezmak, MA; Sanjay J. Mathew, MD; Gerard Sanacora, MD, PhD; James W. Murrough, MD, PhD; Fernando S. Goes, MD; Katherine A. Collins, PhD; LCSW; Brian S. Barnett, MD; Amit Anand, MD

Original Research

A Year in the Shadow of Terror: Longitudinal Effects of the October 7, 2023, Terrorist Attack on PTSD, Depression, Anxiety, and Suicidal Ideation Across Distinct Exposure Groups

J Clin Psychiatry. 2025;86(4):25m15970

Yossi Levi-Belz, PhD; Doron Amsalem, MD; Yoav Groweiss, PhD; Carmel Blank, PhD; Iris Shachar-Lavie, PhD; Yuval Neria, PhD

Original Research

Five-Year Outcomes of First Suicide Attempts: Insights on Lethality, Recurrence, and Mortality

J Clin Psychiatry 2025;86(4):24m15754

Eugènia Nicolau-Subires, MD; Maria Irigoyen-Otiñano, MD, PhD; Laura Arenas-Pijoan, MD; Marina Adrados-Pérez, MD; Carla Albert-Porcar, MD; Lucía Ibarra-Pertusa, MD; María Mur-Laín, MD, PhD; Jorge Lopez-Castroman, MD, PhD; Vicent Llorca-Bofí, MD

<em>N</em>-Acetylcysteine for the Treatment of Co-Occurring Posttraumatic Stress Disorder and Alcohol Use Disorder: A Double-Blind, Randomized Controlled Trial

Original Research

N-Acetylcysteine for the Treatment of Co-Occurring Posttraumatic Stress Disorder and Alcohol Use Disorder: A Double-Blind, Randomized Controlled Trial

J Clin Psychiatry 2025;86(4):25m15803

Sudie E. Back, PhD; Kevin Gray, MD; Amber M. Jarnecke, PhD; Tanya C. Saraiya, PhD; Elizabeth J. Santa Ana, PhD; Therese Killeen, PhD; Jane E. Joseph, PhD; James J. Prisciandaro, PhD; Delisa G. Brown, PhD; Paul J. Nietert, PhD; Tracy Stecker, PhD; Alex Rothbaum, PhD; Jennifer L. Jones, MD; Julianne C. Flanagan, PhD; Kathleen T. Brady, MD, PhD

Original Research

Lumateperone as Adjunctive Therapy in Patients With Major Depressive Disorder: Results From a Randomized, Double-Blind, Phase 3 Trial

J Clin Psychiatry 2025;86(4):25m15848

Suresh Durgam, MD; Willie R. Earley, MD; Susan G. Kozauer, MD; Changzheng Chen, PhD; Hassan Lakkis, PhD; Roger S. McIntyre, MD; Stephen Stahl, MD, PhD

Commentary

Practitioners Providing Care for Persons With Severe Mental Disorders Should Routinely Screen for Metabolic Dysfunction–Associated Steatotic Liver Disease

J Clin Psychiatry. 2025;86(4):25com16021

Roger S. McIntyre, MD, FRCPC; Gia Han Le, HBSc

Clinical and Practical Psychopharmacology

Ketamine-Associated Uropathy During Therapeutic and Nontherapeutic Use: Prevalence, Clinical Features, Mechanisms, and Strategies for Risk Reduction

J Clin Psychiatry. 2025;86(4):25f16083

Chittaranjan Andrade, MD

ASCP Corner

What Is Meant by the Term “Deprescribing,” and Does It Belong in Our Lexicon?

J Clin Psychiatry 2025;86(4):25ac15936

Joseph F. Goldberg, MD; Holly A. Swartz, MD; Rajnish Mago, MD; Roger S. McIntyre, MD; Gin S. Malhi, MD; Joshua D. Rosenblat, MD; Marlene P. Freeman, MD; Eduard Vieta, MD; Michael E. Thase, MD; Mauricio Tohen, MD; Leslie Citrome, MD, MPH

Brief Report

Nonmedical Use and Substance Use Disorder Symptoms Among US Adults Coprescribed Opioids and Benzodiazepines

J Clin Psychiatry 2025;86(4):25br15937

Emily Pasman, PhD; Phil Veliz, PhD; Elizabeth Hoffman, MD; Rebecca Evans-Polce, PhD; Ty S. Schepis, PhD; Megan E. Patrick, PhD; Joshua Truchan, BSN; Timothy E. Wilens, MD; John Jardine, MS; Vita V. McCabe, MD; Sean Esteban McCabe, PhD

Letter to the Editor

Misleading Labeling of <em>S</em>-Methadone as a Novel <em>N</em>-Methyl-D-Aspartate Receptor Antagonist

Letter to the Editor

Misleading Labeling of S-Methadone as a Novel N-Methyl-D-Aspartate Receptor Antagonist

J Clin Psychiatry 2025;86(4):25lr15973

Sergi Ferré, MD, PhD; Michael Michaelides, PhD

Letter to the Editor

Reasons for Maintaining the Classification of Esmethadone as an Investigational Uncompetitive NMDAR Antagonist Rapid Antidepressant: Reply to Ferré and Michaelides

J Clin Psychiatry 2025;86(4):25lr15973a

Sara De Martin, PhD; Stefano Comai, PhD; Andrea Mattarei, PhD; Thomas R. Kosten, MD; Frank J. Vocci, PhD; Charles W. Gorodetzky, MD, PhD; Marco Pappagallo, MD; Paolo L. Manfredi, MD

Letter to the Editor

Psychedelic Therapies: One Drug, Multiple Treatments: Reply to Modesto-Lowe et al

J Clin Psychiatry 2025;86(4):25lr15978a

David A. Bender, MD; Sandeep M. Nayak, MD; Joshua S. Siegel, MD, PhD; David J. Hellerstein, MD; Baris C. Ercal, MD, PhD; Eric J. Lenze, MD

Letter to the Editor

Toward Consensus in Psychedelic-Assisted Therapy: The Critical Role of Psychotherapeutic Support

J Clin Psychiatry 2025;86(4):25lr15978

Vania Modesto-Lowe, MD, MPH; Deanna Sgambato, DMS, MHS; PA-C Margaret Chaplin, MD

Volume 86 • 2025 • 4

Original Research

New Onset Mental Health Diagnosis and Emergent Service Utilization Associated With Bariatric Surgery

Identifying Factors Linked to a Higher Prevalence of Posttraumatic Stress Disorder Among Younger US Military Veterans

Ketamine Reduces Suicidality-Associated Emergency Department Utilization in Patients With Treatment-Resistant Depression: A 6-Month Mirror-Image Study

Relationships Between Body Composition and Mental Health During Pregnancy Are Moderated by Physical Activity and Diet

Comparing the Cognitive Effects of Repeated Intravenous Ketamine and Electroconvulsive Therapy in Patients With Treatment-Resistant Depression: A Secondary Analysis of the ELEKT-D Trial

A Year in the Shadow of Terror: Longitudinal Effects of the October 7, 2023, Terrorist Attack on PTSD, Depression, Anxiety, and Suicidal Ideation Across Distinct Exposure Groups

Five-Year Outcomes of First Suicide Attempts: Insights on Lethality, Recurrence, and Mortality

N-Acetylcysteine for the Treatment of Co-Occurring Posttraumatic Stress Disorder and Alcohol Use Disorder: A Double-Blind, Randomized Controlled Trial

Lumateperone as Adjunctive Therapy in Patients With Major Depressive Disorder: Results From a Randomized, Double-Blind, Phase 3 Trial

Commentary

Practitioners Providing Care for Persons With Severe Mental Disorders Should Routinely Screen for Metabolic Dysfunction–Associated Steatotic Liver Disease

Clinical and Practical Psychopharmacology

Ketamine-Associated Uropathy During Therapeutic and Nontherapeutic Use: Prevalence, Clinical Features, Mechanisms, and Strategies for Risk Reduction

ASCP Corner

What Is Meant by the Term “Deprescribing,” and Does It Belong in Our Lexicon?

Brief Report

Nonmedical Use and Substance Use Disorder Symptoms Among US Adults Coprescribed Opioids and Benzodiazepines

Letter to the Editor

Misleading Labeling of S-Methadone as a Novel N-Methyl-D-Aspartate Receptor Antagonist

Reasons for Maintaining the Classification of Esmethadone as an Investigational Uncompetitive NMDAR Antagonist Rapid Antidepressant: Reply to Ferré and Michaelides

Psychedelic Therapies: One Drug, Multiple Treatments: Reply to Modesto-Lowe et al

Toward Consensus in Psychedelic-Assisted Therapy: The Critical Role of Psychotherapeutic Support

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Volume 86 • 2025 • 4

Original Research

New Onset Mental Health Diagnosis and Emergent Service Utilization Associated With Bariatric Surgery

Identifying Factors Linked to a Higher Prevalence of Posttraumatic Stress Disorder Among Younger US Military Veterans

Ketamine Reduces Suicidality-Associated Emergency Department Utilization in Patients With Treatment-Resistant Depression: A 6-Month Mirror-Image Study

Relationships Between Body Composition and Mental Health During Pregnancy Are Moderated by Physical Activity and Diet

Comparing the Cognitive Effects of Repeated Intravenous Ketamine and Electroconvulsive Therapy in Patients With Treatment-Resistant Depression: A Secondary Analysis of the ELEKT-D Trial

A Year in the Shadow of Terror: Longitudinal Effects of the October 7, 2023, Terrorist Attack on PTSD, Depression, Anxiety, and Suicidal Ideation Across Distinct Exposure Groups

Five-Year Outcomes of First Suicide Attempts: Insights on Lethality, Recurrence, and Mortality

N-Acetylcysteine for the Treatment of Co-Occurring Posttraumatic Stress Disorder and Alcohol Use Disorder: A Double-Blind, Randomized Controlled Trial

Lumateperone as Adjunctive Therapy in Patients With Major Depressive Disorder: Results From a Randomized, Double-Blind, Phase 3 Trial

Commentary

Practitioners Providing Care for Persons With Severe Mental Disorders Should Routinely Screen for Metabolic Dysfunction–Associated Steatotic Liver Disease

Clinical and Practical Psychopharmacology

Ketamine-Associated Uropathy During Therapeutic and Nontherapeutic Use: Prevalence, Clinical Features, Mechanisms, and Strategies for Risk Reduction

ASCP Corner

What Is Meant by the Term “Deprescribing,” and Does It Belong in Our Lexicon?

Brief Report

Nonmedical Use and Substance Use Disorder Symptoms Among US Adults Coprescribed Opioids and Benzodiazepines

Letter to the Editor

Misleading Labeling of S-Methadone as a Novel N-Methyl-D-Aspartate Receptor Antagonist

Reasons for Maintaining the Classification of Esmethadone as an Investigational Uncompetitive NMDAR Antagonist Rapid Antidepressant: Reply to Ferré and Michaelides

Psychedelic Therapies: One Drug, Multiple Treatments: Reply to Modesto-Lowe et al

Toward Consensus in Psychedelic-Assisted Therapy: The Critical Role of Psychotherapeutic Support

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