Case Report July 11, 2024

Clozapine-Related Cecal Volvulus

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Prim Care Companion CNS Disord 2024;26(4):24cr03729

  1. Mortimer AM. Antipsychotic treatment in schizophrenia: atypical options and NICE guidance. Eur Psychiatry. 2003;18(5):209–219. PubMed CrossRef
  2. Siskind D, McCartney L, Goldschlager R, et al. Clozapine v. first- and second-generation antipsychotics in treatment-refractory schizophrenia: systematic review and meta-analysis. Br J Psychiatry. 2016;209(5):385–392. PubMed CrossRef
  3. Howes OD, McCutcheon R, Agid O, et al. Treatment resistant schizophrenia: treatment response and resistance in psychosis (TRRIP) working group consensus guidelines on diagnosis and terminology. Am J Psychiatry. 2017;174(3):216–229. PubMed CrossRef
  4. De Berardis D, Rapini G, Olivieri L, et al. Safety of antipsychotics for the treatment of schizophrenia: a focus on the adverse effects of clozapine. Ther Adv Drug Saf. 2018;9(5):237–256. PubMed CrossRef
  5. Novartis Pharmaceuticals Canada Inc. Clozaril Product Monograph. Revised. 2004.
  6. Every-Palmer S, Inns SJ, Grant E, et al. Effects of clozapine on the gut: cross-sectional study of delayed gastric emptying and small and large intestinal dysmotility. CNS Drugs. 2019;33(1):81–91. PubMed
  7. Hibbard KR, Propst A, Frank DE, et al. Fatalities associated with clozapine-related constipation and bowel obstruction: a literature review and two case reports. Psychosomatics. 2009;50(4):416–419. PubMed CrossRef
  8. Aneja J, Varshney V, Ks S, et al. Clozapine triggering cecal volvulus in a patient with malrotation and schizophrenia: side effect that needs emphasis. Cureus. 2020;12(5):e7971. PubMed CrossRef
  9. Tampakis A, Droeser RA, Tampaki EC, et al. A case of cecal volvulus mimicking Ogilvie syndrome in a hospitalized patient with a pelvis fracture. Ann Med Surg (Lond). 2016;7:55–57. PubMed CrossRef
  10. Atamanalp SS, Ozogul B, Kisaoglu A. Cecal volvulus: a rare cause of intestinal obstruction. Eurasian J Med. 2012;44(2):115–116. PubMed CrossRef
  11. Hayes G, Gibler B. Clozapine-induced constipation. Am J Psychiatry. 1995;152(2):298. PubMed CrossRef