Because this piece does not have an abstract, we have provided for your benefit the first 3 sentences of the full text.
To the Editor: The atypical antipsychotic clozapine is the most effective medication for treatment-resistant schizophrenia and schizoaffective disorder, improving psychopathology and quality of life; however, its use is limited by the risk of neutropenia (2.7%) and agranulocytosis (0.9%). In France, after initiation of clozapine, blood monitoring must occur on a weekly basis for the first 4 months, after which patients undergo monthly monitoring.
Lithium carbonate is known to increase the white blood cell (WBC) count by a mechanism that is still unclear but that may involve demargination, stimulation of granulocyte-macrophage colony-stimulating factor, and stimulation of cytokines.
Free Access: Please Log In
This content is completely free—but you need to be logged in to read the full article. If you already have an account, please log in below. Otherwise, register for free to unlock instant access.
Please sign in or purchase this PDF for $40.00.