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Letter to the Editor

Gabapentin in the Treatment of Posttraumatic Stress Disorder

Timothy R. Berigan, DDS, MD

Published: June 1, 2000

Article Abstract

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Sir: Gabapentin is a newer anticonvulsant approved for useas an adjunct agent in the treatment of partial seizures with orwithout secondary generalization.1 Recent publications indicatethat gabapentin has been useful in a wide array of psychiatricconditions including anxiety disorders,2 alcohol withdrawal,3 bipolardisorder,4 behavioral disorders,5,6 and even antidepressantinducedbruxism.7 Although its exact mechanism of action isnot known,1 it is structurally related to g-aminobutyric acid(GABA), but does not interact with GABA receptors.8

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