Case Report March 29, 2022

High-Dose Intranasal Bupropion Insufflation

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Prim Care Companion CNS Disord 2022;24(2):21cr03056

  1. Stall N, Godwin J, Juurlink D. Bupropion abuse and overdose. CMAJ. 2014;186(13):1015. PubMed CrossRef
  2. Dwoskin LP, Rauhut AS, King-Pospisil KA, et al. Review of the pharmacology and clinical profile of bupropion, an antidepressant and tobacco use cessation agent. CNS Drug Rev. 2006;12(3–4):178–207. PubMed CrossRef
  3. Lewis JC, Sutter ME, Albertson TE, et al. An 11-year review of bupropion insufflation exposures in adults reported to the California Poison Control System. Clin Toxicol (Phila). 2014;52(9):969–972. PubMed CrossRef
  4. Yoon G, Westermeyer J. Intranasal bupropion abuse: case report. Am J Addict. 2013;22(2):180–180. PubMed CrossRef
  5. Langguth B, Hajak G, Landgrebe M, et al. Abuse potential of bupropion nasal insufflation: a case report. J Clin Psychopharmacol. 2009;29(6):618–619. PubMed CrossRef
  6. Hill S, Sikand H, Lee J. A case report of seizure induced by bupropion nasal insufflation. Prim Care Companion J Clin Psychiatry. 2007;9(1):67–69. PubMed CrossRef
  7. Reeves RR, Ladner ME. Additional evidence of the abuse potential of bupropion. J Clin Psychopharmacol. 2013;33(4):584–585. PubMed CrossRef
  8. Khurshid KA, Decker DH. Bupropion insufflation in a teenager. J Child Adolesc Psychopharmacol. 2004;14(1):157–158. PubMed CrossRef
  9. Welsh CJ, Doyon S. Seizure induced by insufflation of bupropion. N Engl J Med. 2002;347(12):951. PubMed CrossRef
  10. Kim D, Steinhart B. Seizures induced by recreational abuse of bupropion tablets via nasal insufflation. CJEM. 2010;12(2):158–161. PubMed CrossRef
  11. Dhillon S, Yang LPH, Curran MP. Bupropion: a review of its use in the management of major depressive disorder. Drugs. 2008;68(5):653–689. PubMed CrossRef
  12. Stassinos GL, Klein-Schwartz W. Bupropion “abuse” reported to US poison centers. J Addict Med. 2016;10(5):357–362. PubMed CrossRef
  13. Kate N, Grover S, Kumar S, et al. Bupropion-induced hyponatremia. Gen Hosp Psychiatry. 2013;35(6):681.e11–681.e12. PubMed CrossRef
  14. Kim CS, Choi JS, Bae EH, et al. Hyponatremia associated with bupropion. Electrolyte Blood Press. 2011;9(1):23–26. PubMed CrossRef
  15. Munjal S, Smolin Y. Bupropion induced hyponatremia in an elderly patient: a case report and review of the literature. Case Rep Psychiatry. 2016;2016:5103471. PubMed CrossRef