The Primary
Care Companionfor CNS Disorders

Advancing primary care with essential peer-reviewed research and insights into CNS disorders

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More Articles from The Primary Care Companion for CNS Disorders

PCC
Generative AI in Mental Health
Rounds in the General Hospital

Generative AI in Mental Health

August 25, 2026

As patients rely more on generative AI to assess and manage symptoms, they may mistake its output for professional advice and be unable to gauge accuracy, quality, or biases.
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PCC
Aripiprazole-Induced Hiccups
Case Report

Aripiprazole-Induced Hiccups

August 25, 2026

A 29-year-old man hospitalized for psychotic symptoms in the context of methamphetamine experienced persistent hiccups after starting aripiprazole.
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PCC
Anxiety, Depression, and Substance Use in Schizophrenia
Original Research

Anxiety, Depression, and Substance Use in Schizophrenia

August 20, 2026

Early screening and management of anxiety and depressive symptoms in schizophrenia is crucial, as their presence significantly correlates with illness severity and may shape long-term functional outcomes.
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PCC
Renal Agenesis, Dysmorphism, and Schizophrenia
Case Report

Renal Agenesis, Dysmorphism, and Schizophrenia

August 18, 2026

The authors report a case of treatment-resistant schizophrenia with unilateral renal agenesis and minor physical anomalies, highlighting this rare association as well as treatment implications.
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PCC
Unexpected Improvement in Obsessive-Compulsive Disorder Symptoms Following Initiation of Bupropion
Case Report

Unexpected Improvement in Obsessive-Compulsive Disorder Symptoms Following Initiation of Bupropion

August 18, 2026

A 23-year-old woman with OCD and comorbid depression experienced an unexpected improvement in OCD symptoms following initiation of bupropion.
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PCC
Peduncular Hallucinosis With Right Thalamic Cavernous Angioma
Case Report

Peduncular Hallucinosis With Right Thalamic Cavernous Angioma

August 18, 2026

A 56-year-old woman developed visual and auditory hallucinations, delusions of jealousy and possession, and cognitive impairment associated with a thalamic lesion
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PCC
Neuromodulatory Technologies for CNS Disorders
Rounds in the General Hospital

Neuromodulatory Technologies for CNS Disorders

August 13, 2026

Neuromodulatory devices and wearables are transforming psychiatric care; this case-based review covers FDA-approved uses, contraindications, and clinical integration for depression, PTSD, and pain.
, , , et al
PCC
Homelessness and Housing Insecurity
Rounds in the General Hospital

Homelessness and Housing Insecurity

August 13, 2026

Individuals who experience homelessness have high rates of medical and psychiatric illness and face barriers to care; vulnerable populations include mothers with dependent children who have experienced domestic violence,…
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PCC
Clozapine, Xanomeline-Trospium, and Catatonia
Rounds in the General Hospital

Clozapine, Xanomeline-Trospium, and Catatonia

August 11, 2026

Abrupt clozapine discontinuation during a cross-taper to xanomeline/trospium chloride can trigger catatonia. Learn how overlapping cholinergic mechanisms complicate this transition and how to manage withdrawal-induced catatonia.
, , , et al
PCC
Volitional Mutism in Adulthood
Case Report

Volitional Mutism in Adulthood

August 6, 2026

The authors present a case of volitional mutism in a 42-year-old woman and highlight the differential diagnosis.
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PCC
Mushroom-Based Supplement Worsens Psychosis
Case Report

Mushroom-Based Supplement Worsens Psychosis

August 4, 2026

This case illustrates potential neuropsychiatric risks associated with mushroom-based dietary supplements in individuals with neurological vulnerabilities such as cerebral palsy.
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PCC
Impact of Religious Practices on Health
Rounds in the General Hospital

Impact of Religious Practices on Health

August 4, 2026

The importance of patients’ spiritual and religious practices is frequently under-appreciated by health care providers. Read this case vignette and discussion to find out more.
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