The potential side effects of psychiatric medications are a critical consideration in patient care. The Journal of Clinical Psychiatry is dedicated to providing clinicians with comprehensive insights into the adverse effects associated with various treatments. Our expert editors curate content that delves into the physiological and psychological impacts of medications, from weight gain and sedation to mood changes and cognitive disturbances. As the field of psychopharmacology continues to evolve, our journal remains a trusted resource for understanding the balance between therapeutic benefits and potential risks.

Recently published articles about Side Effects

PCC
Testosterone-Induced Psychosis in Klinefelter Syndrome
Case Report

July 30, 2026

The authors report a rare case of acute psychosis following long-term parenteral testosterone replacement in a patient with undiagnosed Klinefelter syndrome.
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PCC
Abrupt Smoking Cessation With Tirzepatide
Case Report

July 30, 2026

The authors present a case of sudden, sustained smoking cessation associated with the initiation of tirzepatide in a 53-year-old woman and highlight a novel possible mechanism of action for...
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PCC
Amiodarone-Induced Thyrotoxicosis and Mania
Case Report

July 28, 2026

A 66-year-old man diagnosed with amiodarone-induced thyrotoxicosis who presented to the emergency department with symptoms of mania.
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PCC
Mirtazapine-Induced Severe Hyponatremia
Case Report

July 16, 2026

A 30-year-old man developed severe hyponatremia after starting mirtazapine, highlighting the importance of closely monitoring sodium levels when starting any antidepressant in patients already taking oxcarbazepine.
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PCC
Fluoxetine-Induced Liver Injury
Case Report

June 30, 2026

The authors report a case of fluoxetine-induced acute liver injury in a young woman to highlight the possibility of severe hepatic damage with a widely used antidepressant and emphasize...
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PCC
Visual Snow Syndrome and Bupropion
Case Report

June 18, 2026

A patient in their 60s with advanced macular degeneration complicated by bilateral geographic atrophy presented with new-onset visual disturbances shortly after initiation of bupropion for depression.

Recent JCP Articles on Side Effects

JCP
Metformin for Prevention of Antipsychotic-Induced Weight Gain: The Optimal Strategy
Letter to the Editor

April 6, 2026

Dr Huang discusses the potential for B12 deficiency in patients coprescribed antipsychotics and metformin.
JCP
Vitamin B12 Deficiency Risk With Metformin for Weight Management in Second-Generation Antipsychotic Recipients: Reply to Mulsant et al
Letter to the Editor

March 18, 2026

Daggolu and Chen reply to a letter commenting on their study of metformin use in patients receiving second-generation antipsychotics.
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JCP
Concurrent Metformin and Second-Generation Antipsychotics: The Need to Add Vitamin B12
Letter to the Editor

March 18, 2026

The authors recommend vigilance for potential B12 deficiency when coprescribing metformin and antipsychotics.
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Recent PCC Articles on Side Effects

PCC
Osmotic Demyelination Syndrome Presenting as EPS
Case Report

April 21, 2026

A 44-year-old woman was initially referred for presumed domperidone-induced extrapyramidal symptoms, but further workup uncovered a complex interplay of hyponatremia, demyelination, and neuroleptic hypersensitivity.
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PCC
Acitretin, Homocysteine, and Neuropsychiatric Symptoms
Case Report

April 14, 2026

This report describes a case of acitretin-associated hyperhomocysteinemia that induced neuropsychiatric symptoms in a patient with chronic plaque psoriasis, highlighting the need for monitoring.
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PCC
Dose-Dependent Valproic Acid–Induced Hyperkalemia
Case Report

April 9, 2026

The authors present the case of a young man with bradycardia and Jacobs syndrome, in which a clear, dose-dependent relationship between valproic acid and hyperkalemia was observed.
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The latest news on Side Effects

Featured Side Effects Research

JCP
Severity of Antipsychotic-Induced Cervical Dystonia by Algorithm-Based Rating System
Original Research

April 15, 2024

Rater consensus data were compared with deviation angle data using AI-based deviation angle measurement technology. With the range of tilt angles found in the study, the authors propose a...
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JCP
Associations of Valproate Doses With Weight Gain in Psychiatric Patients
Original Research

March 27, 2024

Valproate dose increase of 500 mg was associated with a weight change of +0.52% per month over a year. No associations were found between valproate dose and blood glucose,...
, , , et al
JCP
CYP2D6 Genotyping and Adverse Drug Reactions in Depression
Original Research

January 17, 2024

Genetic testing of CYP2D6 did not show that predicted poor drug metabolism led to increased adverse drug reactions in patients with depression.
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PCC
Aripiprazole-Induced Pathological Gambling
Case Report

May 7, 2026

A 27-year-old man with a history of substance abuse developed a new-onset compulsive gambling pattern within weeks of starting aripiprazole.
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PCC
Clozapine-Associated Pulmonary Embolism
Case Report

May 5, 2026

A 48-year-old woman with schizoaffective disorder taking clozapine developed acute pulmonary embolism despite negative D-dimer results.
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JCP
Validation for the Tardive Dyskinesia Impact Scale, a Patient-Reported Outcome Measure in Valbenazine Clinical Trials
Narrative Review

April 29, 2026

The TDIS followed a similar trajectory to other clinician- and patient-reported outcomes measured in tardive dyskinesia clinical trials, and a change of 4 points in total score is considered...
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JCP
The Patient Perspective on Tardive Dyskinesia
Commentary

April 29, 2026

Patients’ perspectives on their experiences with tardive dyskinesia provide critical insights that go beyond the information provided by clinical assessments.
PCC
Diphenhydramine and Dextromethorphan Overdose
Case Report

April 28, 2026

The authors describe a case of intentional overdose with diphenhydramine and extended-release dextromethorphan-guaifenesin that initially presented with anticholinergic toxicity and later evolved into serotonin toxicity.
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PCC
Psychotropic-Induced Reversible Cerebral Vasoconstriction Syndrome
Case Report

April 23, 2026

This case reinforces the importance of monitoring for acute neurologic symptoms in patients treated with high-dose selective serotonin reuptake inhibitors.
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