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Letter to the Editor

The Use of Alosetron to Treat SSRI-Induced Gastrointestinal Symptoms

Timothy R. Berigan, DDS, MD; and Karl N. Zeff. MD

Published: August 1, 2000

Article Abstract

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Sir: The use of selective serotonin reuptake inhibitors (SSRIs) across a wide range of psychiatric disordersis well documented in the literature.1 The SSRIs are generally well tolerated and dosed once daily, features thatenhance compliance.2 However, among the common side effects of SSRIs are gastrointestinal reactions includingnausea, diarrhea, loose stools, and constipation.3

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