When Green Becomes Mean: Green Tea Extract Reduces Ziprasidone's Effect and Causes Psychosis

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Ziprasidone is an atypical antipsychotic that is approved by the US Food and Drug Administration for the treatment of schizophrenia, acute mania, and mixed states associated with bipolar disorder. Food influences the bioavailability of ziprasidone, and guidelines advise taking ziprasidone with meals containing approximately 500 kilocalories. Failure to do so can result in a decrease in intestinal absorption by 50% and inconsistent efficacy.