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Letter to the Editor

Lamotrigine-Induced Neutropenia in a Woman With Schizoaffective Disorder

Piyush Das, MD; Sriram Ramaswamy, MD; Monica Arora, MD; Irina Samuels, MD; and Teri L. Gabel, PharmD, BCPP

Published: December 14, 2007

Article Abstract

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Sir: Lamotrigine is a drug of the phenyltriazine class withinhibitory effects on voltage-sensitive sodium channels alongwith modulating effects on calcium and potassium channels.Lamotrigine is also a weak dihydrofolate reductase inhibitor.The drug is currently approved by the U.S. Food and Drug Administrationfor maintenance treatment in bipolar type I disorder.

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