The Primary
Care Companionfor CNS Disorders

Advancing primary care with essential peer-reviewed research and insights into CNS disorders

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PCC
Alcohol Use Disorders in Primary Care
Rounds in the General Hospital

Alcohol Use Disorders in Primary Care

May 21, 2026

Patients with major depressive disorder and a comorbid AUD often present with more severe manifestations, including thoughts of suicide, co-occurring personality disorders, and higher rates of smoking.
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PCC
ECT for Psychosis in Huntington Disease-Like 2
Case Report

ECT for Psychosis in Huntington Disease-Like 2

May 19, 2026

A 47-year-old woman with genetically confirmed Huntington disease-like 2 had refractory psychosis and functional decline but responded well to electroconvulsive therapy.
, , , et al
PCC
Manifestations Associated With CNS Lesions
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Manifestations Associated With CNS Lesions

May 19, 2026

Neuropsychiatric manifestations of brain metastases are varied, although certain symptoms can be associated with the brain region in which there is a metastasis; lesions that affect certain parts of…
, , , et al
PCC
Adjunct Memantine for Inappropriate Sexual Behavior
Case Report

Adjunct Memantine for Inappropriate Sexual Behavior

May 14, 2026

Two patients with intellectual disability and major neurocognitive disorder exhibited inappropriate sexual behavior that significantly decreased after memantine was added as adjunctive therapy.
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PCC
From Physical to Digital: Hoarding Phenomena in Obsessive-Compulsive Disorder
Case Report

From Physical to Digital: Hoarding Phenomena in Obsessive-Compulsive Disorder

May 14, 2026

This case illustrates how hoarding phenomenology can manifest in digital environments, which offer virtually unlimited storage, anonymity, and low visibility.
, , , et al
PCC
Differentiating Bipolar and Other Psychiatric Disorders
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Differentiating Bipolar and Other Psychiatric Disorders

May 12, 2026

Diagnosis of bipolar spectrum disorder is often complicated, as most patients present for care during depressive episodes, which are more frequent than hypomanic or manic episodes.
, , , et al
PCC
Aripiprazole-Induced Pathological Gambling
Case Report

Aripiprazole-Induced Pathological Gambling

May 7, 2026

A 27-year-old man with a history of substance abuse developed a new-onset compulsive gambling pattern within weeks of starting aripiprazole.
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PCC
Strategies for Documenting the Medical Record
Rounds in the General Hospital

Strategies for Documenting the Medical Record

May 7, 2026

Documentation should be objective and relevant, especially in psychosocially complex cases—too much information can interfere with establishing the correct diagnosis and treatment plan, while too little increases risk of…
, , , et al
PCC
Readability of Self-Reported Psychosis Measures
Original Research

Readability of Self-Reported Psychosis Measures

May 5, 2026

Most psychosis self-report measures are written above recommended reading levels, reducing accessibility for many patients with cognitive, educational, or symptomatic limitations.
, , , et al
PCC
Clozapine-Associated Pulmonary Embolism
Case Report

Clozapine-Associated Pulmonary Embolism

May 5, 2026

A 48-year-old woman with schizoaffective disorder taking clozapine developed acute pulmonary embolism despite negative D-dimer results.
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PCC
Polydipsia-Related Hyponatremia in Autism
Case Report

Polydipsia-Related Hyponatremia in Autism

April 30, 2026

The authors present the case of a 10-year-old boy with autism who presented to the ED with hyponatremia-related seizures due to compulsive water drinking.
, , , et al
PCC
Diphenhydramine and Dextromethorphan Overdose
Case Report

Diphenhydramine and Dextromethorphan Overdose

April 28, 2026

The authors describe a case of intentional overdose with diphenhydramine and extended-release dextromethorphan-guaifenesin that initially presented with anticholinergic toxicity and later evolved into serotonin toxicity.
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