Bupropion-Induced Spontaneous Ejaculations

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Bupropion is an antidepressant that inhibits dopamine and norepinephrine reuptake in the brain. Of the antidepressants, it is considered to have the least sexual side effects and is often prescribed to treat selective serotonin reuptake inhibitor-associated sexual dysfunction. However, there are rare reports of premature ejaculation and spontaneous orgasm associated with bupropion.