Gynecomastia Associated With Citalopram

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There have been several reports regarding the development of gynecomastia in patients on selective serotonin reuptake inhibitors (SSRIs) and serotonin-norepinephrine reuptake inhibitors, but to our knowledge, this is the first reported case in a patient taking citalopram. Our literature search included PubMed and Ovid databases and the keywords SSRI, citalopram, gynecomastia, and hyperprolactinemia. The exact mechanisms are still unclear, but SSRI use has been associated with hyperprolactinemia and perturbations of the hypothalamic-pituitary-testicular (HPT) axis.