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Case Series
Esketamine Augmented With Dextromethorphan/Bupropion for Treatment Resistant Depression: A Case Series
November 3, 2025
Three patients with TRD who had no or partial response to esketamine monotherapy as part of a clinical trial received augmentation with dextromethorphan/bupropion 45 mg/105 mg daily.
Original Research
Neurocognition and Impulsivity in Veterans with Bipolar Spectrum Disorders: Suicide Attempters Versus Nonattempters
October 29, 2025
Poorer working memory is associated with suicide attempt independent of depression, while verbal learning impairments associated with suicide attempt may be influenced by depression.
Vol 86 • 2025 • Number 3
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Original Research
Treatment Use and Preference in a Diverse Sample of Women With Mood Disorders
Original Research
Klotho and Matrix Metalloproteinase-9 Levels and Their Association with Inhibitory Dyscontrol in Adolescents with First-Episode Major Affective Disorders
Original Research
Niacin-Induced Response in Early Psychosis
Original Research
Early Ketamine Response Reduces Suicidal Events at 3 Months
Letter to the Editor
Suicide Risk among Patients with Bipolar Disorder: Sleep Disruption versus Benzodiazepine Use
Original Research
Effect of Nature Videos on the Burden of Caregivers of Patients with Dementia
Original Research
Original Research
Brief Video Intervention to Increase Treatment-Seeking Intentions in Young Adults
October 27, 2025
This brief video intervention was associated with greater increases in treatment-seeking intentions in people with self-reported psychiatric symptoms who were not previously engaged in the mental healthcare system and…
Original Research
Autoimmune Diseases, Treatments, and Dementia Risk: A Population-Based Case-Control Study from Taiwan
October 15, 2025
Thirteen autoimmune diseases were linked with an elevated dementia risk, particularly Behçet’s disease, multiple sclerosis, and lupus. Associations with vascular dementia were stronger than with Alzheimer’s disease.
Review Articles
Review Article
Cognitive Effects of ECT in Schizophrenia: A Review
June 5, 2024
ECT was not associated with any significant cognitive deficits in people with treatment-resistant schizophrenia across global cognition, attention, language, visuospatial function, and executive function domains. The majority of studies…
Read articles from ASCP Corner
Letters to the Editor
Letter to the Editor
Reasons for Maintaining the Classification of Esmethadone as an Investigational Uncompetitive NMDAR Antagonist Rapid Antidepressant: Reply to Ferré and Michaelides
September 8, 2025
The authors reply to Ferré and Michaelides’ letter commenting on their recent study of long-term esmethadone treatment in MDD.
Commentaries
Commentary
Beyond the Boxed Warning: A Call for Regulation of Psychiatry’s Most Teratogenic Drug
October 6, 2025
The authors assert that while valproate remains invaluable for certain severe conditions, the high risk of teratogenicity means stringent safeguards are needed to regulate its use by individuals capable…
Commentary
Prioritizing Mental Health to Optimize Perinatal, Fetal, and Neonatal Outcomes
September 24, 2025
Following an FDA panel discussion on use of SSRIs in pregnancy, the authors highlight the need for balanced conversations and shared decision-making accounting for the risks of untreated disease…
Commentary
Practitioners Providing Care for Persons with Severe Mental Disorders Should Routinely Screen for Metabolic Dysfunction–Associated Steatotic Liver Disease
September 10, 2025
Persons with severe mental illnesses should be routinely screened for MASLD as part of a psychiatric and medical assessment that includes social and economic determinants of health, risk factors…
More JCP Articles
Original Research
Brexpiprazole for the Treatment of Co-Occurring Schizophrenia and Substance Use Disorder
October 13, 2025
This pilot trial suggests that brexpiprazole might be beneficial in reducing substance craving and use and improve quality of life in this difficult-to-treat patient population.
Brief Report
Treatment with (Es)ketamine in Catatonia: A Systematic Review of Case Reports
October 13, 2025
Recent evidence suggests that NMDA receptor antagonists, such as ketamine, may offer benefit in catatonia. This systematic review was conducted to evaluate the efficacy and safety of ketamine and…
Original Research
Effects of Interpersonal and Social Rhythm Therapy on Suicidal Ideation in Adults with Bipolar II Depression
September 29, 2025
There was no significant difference in suicidal ideation in those receiving IPSRT plus placebo vs IPSRT plus quetiapine. IPSRT has the potential to mitigate suicidal ideation in patients with…
Original Research
Aripiprazole or Bupropion Augmentation vs Switching to Bupropion in Treatment Resistant Depression
September 22, 2025
In this model, augmentation with bupropion better balanced efficacy and tolerability in TRD in adults under 85 than did switching to bupropion or augmentation with aripiprazole. Augmentation with aripiprazole…
