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Care Companionfor CNS Disorders

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PCC
Bupropion-Dextromethorphan for Clinically Challenging Apathy
Case Report

April 2, 2026

This case shows potential benefits of glutamate system–activating medication in addressing clinically challenging apathy in a 44-year-old man with depression.
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PCC
Strategies for Managing Dyspnea
Rounds in the General Hospital

April 2, 2026

Pharmacologic approaches and behavioral and psychological interventions such as mindfulness, relaxation, and CBT can mitigate dyspnea and associated anxiety.
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PCC
A Unique Manifestation of Postpartum OCD
Case Report

March 31, 2026

This report explores the case of a woman with postpartum OCD, who exhibited a unique compulsion of taking excessive photos and videos of her surroundings.
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PCC
SUD Referrals Among SMI Inpatients and the NHHSRA
Original Research

March 31, 2026

This study evaluates the performance of the New Hampshire Hospital Screening and Referral Algorithm and describes the characteristics of inpatients with serious mental illness referred for substance use disorder…
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PCC
Attitudes of ED Nurses Toward Violent Patients
Original Research

March 26, 2026

Staff attitudes significantly influence aggression management, with over half of surveyed nurses holding neutral—not positive—views on causes and management.
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PCC
Mesial Temporal Sclerosis and Juvenile Myoclonic Epilepsy
Case Report

March 26, 2026

The authors present a rare case of coexisting right mesial temporal sclerosis and juvenile myoclonic epilepsy, underscoring the challenges in dual epilepsy syndromes and the importance of individualized, multidisciplinary…
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Figure—Magazine cover highlights articles on suicide attempts, family support, impulsivity, grief, and bipolar disorder care.

Vol 28 • 2026 • Number 1

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Original Research

Suicidal Mental Imagery in Suicide Attempters

Original Research

Family Support for Patients With Substance Use Disorders

Rounds in the General Hospital

Diagnosing and Treating Impulsivity

Rounds in the General Hospital

Managing Grief and Bereavement

Brief Report

Measurement-Based Care for Bipolar Disorder

Rounds in the General Hospital

Treatment and Referral for AUD in Primary Care
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Rounds in the General Hospital Rounds from Banner Alzheimer's Institute

Original Research

PCC
Health Belief Model and Treatment Adherence in Dissociative Disorders
Original Research

March 24, 2026

This study examined how health belief model constructs influence treatment adherence among patients with dissociative disorders and how demographic variables influence that relationship.
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PCC
Ultra–Low-Dose Mirtazapine for Chronic Insomnia
Original Research

March 10, 2026

In patients with insomnia disorder, a clinically relevant effect was seen with low-dose mirtazapine (3.75 mg) on insomnia severity from 1–3 months.
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PCC
Depression and Cardiovascular Disease in Aging Populations
Original Research

March 3, 2026

Even infrequent depressive symptoms are associated with elevated CVD risk in older adults, and those with both depressive symptoms and obesity or smoking have higher odds.
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Review Articles

PCC
Role of tDCS in Autism
Meta-Analysis

March 12, 2026

Transcranial direct current stimulation improves core autism spectrum disorder symptoms, particularly social responsiveness and behavioral regulation, with stimulation of the dorsolateral prefrontal cortex showing the greatest benefit.
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PCC
Gender-Affirming Surgery, Gender Dysphoria, and QOL
Review Article

November 11, 2025

Those who receive gender dysphoria treatment at a younger age may experience lower rates of suicidal ideation, underscoring potential mental health benefits of timely intervention.
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PCC
Improving Community Mental Health Care
Narrative Review

October 9, 2025

This review highlights critical areas for enhancing the quality and sustainability of community mental health services.
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PCC
Precision Psychiatry for Depression Treatment
Narrative Review

September 9, 2025

Novel precision medicine tools in depression aim to identify the optimal treatment for each patient and have the potential to significantly improve depression management by guiding treatment selection for…
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PCC
Incretin Therapies: A New Tool to Combat Metabolic Consequences of Antipsychotic Use
Narrative Review

September 4, 2025

Incretin therapies have emerged as a promising treatment option with potential benefits for mitigating cardiometabolic side effects associated with antipsychotics; however, clinical trials have often excluded psychiatric populations.
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PCC
Climate Change and Mental Health
Review Article

July 24, 2025

This scoping review highlights the significant impact of climate change on mental health in India, particularly among individuals from lower socioeconomic backgrounds in rural areas.
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Rounds in the General Hospital

PCC
Administering ECT to Critically Ill Patients
Rounds in the General Hospital

March 5, 2026

ECT can be lifesaving for critically ill individuals with severe psychiatric and neuropsychiatric conditions; however, cardiac monitoring is essential.
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PCC
Understanding the Impact of Moral Injury
Rounds in the General Hospital

February 26, 2026

Healing of moral injuries requires truth-telling, communal recognition, and moral repair—not just medication or cognitive restructuring.
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PCC
Preventing Physician Burnout
Rounds in the General Hospital

February 10, 2026

The authors clarify misconceptions about burnout and depression and identify best practices and approaches for burnout at the individual and institutional level.
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PCC
Diagnosis and Management of Rage
Rounds in the General Hospital

December 23, 2025

This article offers a practical framework for distinguishing rage from irritability and impulsivity, identifying underlying neuropsychiatric drivers, and guiding evidence-based management across conditions including PTSD, TBI, and mood disorders.
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PCC
Facilitating Academic Success for Clinicians
Rounds in the General Hospital

December 16, 2025

Many clinicians, experience “imposter syndrome,” which can foster the false belief that they are unqualified for promotion.
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PCC
Using Digital Technologies to Avoid Doctor’s Orders
Rounds in the General Hospital

December 2, 2025

The availability of portable technologies and application-based services can complicate caretaking in the hospital setting, as patients can circumvent medical recommendations.
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Case Reports

PCC
Between Crisis and Clarity: Steroid-Induced Psychosis in Addison Disease
Case Report

March 24, 2026

This case highlights a rare but clinically significant dilemma: balancing essential corticosteroid replacement against neuropsychiatric toxicity.
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PCC
Mania and Cerebral Amyloid Angiopathy
Case Report

March 19, 2026

This report details a case in which a patient presented with mania in the setting of cerebral amyloid angiopathy and hypertension that did not abate until treatment with antihypertensives.
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PCC
Atypical Presentation of Autoimmune Encephalitis
Case Report

March 19, 2026

A 23-year-old woman presented with probable antibody-negative autoimmune encephalitis that initially mimicked a primary psychiatric disorder.
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PCC
Tacrolimus-Induced Parasomnia Posttransplantation
Case Report

March 17, 2026

The authors present a rare case of tacrolimus-induced parasomnia, adding to the body of evidence on its neurotoxic potential.
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PCC
Clozapine-Induced Antiphospholipid Syndrome
Case Report

March 12, 2026

A 68-year-old man with no pre‐existing risk factors experienced clozapine-induced antiphospholipid syndrome and a deep vein thrombosis.
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PCC
Caffeine for ICI Encephalitis
Case Report

March 5, 2026

With the increased use of immune checkpoint inhibitors, the potential for aseptic encephalitis poses a unique challenge to patient rehabilitation.
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Letter to the Editor

PCC
Psychosis and Kratom
Letter to the Editor

March 10, 2026

The authors discuss the possible association between psychosis and kratom use.
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PCC
CTRA, Stress, and Yoga
Letter to the Editor

February 24, 2026

The authors examine the historical context of stress, the neurobiological mechanisms of conserved transcriptional response to adversity and stress, and how yoga practices counteract its effects.
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PCC
Psychotropic-Related Aspiration Hazards
Letter to the Editor

February 10, 2026

The authors discuss the importance of a choking prevention policy to identify those at heightened risk for choking hazards, particularly psychiatric patients.
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PCC
Lysing Catatonia to Uncover the Driving Illness
Letter to the Editor

January 29, 2026

The author comments on a recent PCC article and offers an alternative diagnostic perspective.
PCC
Clarifying the Delirium in Bell’s Mania: Reply to Intrator
Letter to the Editor

January 29, 2026

The authors respond to a letter to the editor commenting on their article.
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PCC
Kratom-Induced Psychosis
Letter to the Editor

January 8, 2026

The author comments on the complexity of substance-induced presentations, particularly those related to newly available psychoactive substances such as kratom.

More Articles from The Primary Care Companion for DNS Disorders

PCC
Recreational Ketamine-Induced Uropathy
Brief Report

March 19, 2026

Two patients with chronic recreational ketamine use presented with urinary frequency, urgency, dysuria, and hematuria in the absence of infection.
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PCC
Misophonia With Psychiatric Comorbidities
Case Report

March 3, 2026

This case highlights the need for enhanced recognition of misophonia, integrated care pathways, and improved mental health infrastructure in low- and middle-income countries.
PCC
Intranasal Tapentadol Dependence
Case Report

February 26, 2026

The authors present 2 cases of intranasal tapentadol dependence marked by rapid tolerance and significant physical and psychological issues.
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PCC
Practice Relevance as the North Star: A Message From the Editor
Editorial

February 26, 2026

Dr Culpepper, Editor in Chief, outlines manuscript selection criteria for the PCC, prioritizing clinical relevance to primary care and frontline psychiatric settings, and thanks peer reviewers for their service.
PCC
Validation of the APREMDI Scale for Brazilian Portuguese
Original Research

February 19, 2026

The APREMDI scale allows clinicians to quantitatively assess patients’ perceptions of respect and dignity during hospitalization, helping to identify subtle dignity violations that may compromise recovery and satisfaction.
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PCC
Calcineurin Inhibitor–Induced Psychosis
Case Report

February 17, 2026

The authors report a case of delayed and recurrent calcineurin inhibitor–induced psychosis with both tacrolimus and cyclosporine, highlighting the need to better understand host vulnerability and risk stratification.
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PCC
Arm EMG and Detection of REM Sleep Without Atonia
Case Report

February 17, 2026

This case highlights the importance of utilizing arm EMG to accurately detect REM sleep without atonia, as REM sleep behavior disorder often precedes the development of α-synucleinopathies, such as…
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PCC
Long-Term High-Intensity Drinking
Case Report

February 12, 2026

This case underscores the need to recognize episodic high-intensity alcohol use as a clinically relevant presentation that carries medical and social risks despite the absence of daily drinking.
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PCC
Daylight Duration and rTMS Outcomes in Treatment-Resistant Depression
Original Research

February 3, 2026

The authors examine the possible impact of daylight duration during the course of repetitive transcranial magnetic stimulation on its efficacy in patients with treatment-resistant depression.
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PCC
Periodic Catatonia in an Adult With Autism
Case Report

February 3, 2026

The authors report a case of periodic catatonia in a 30-year-old man with autism spectrum disorder, with no other identifiable psychiatric or neurological comorbidities, that responded to lithium prophylaxis.
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PCC
When the Labs Don’t Add Up: Factitious Disorder and Successful Treatment
Case Report

January 27, 2026

This case of a 37-year-old woman, who presented to the ED with recurrent syncope and acute kidney injury, demonstrates successful long-term treatment of factitious disorder, highlighting the complexities of…
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PCC
High-dose Veterinary AMP Dependence
Case Report

January 27, 2026

A 41-year-old man self-administered mega-doses of veterinary adenosine monophosphate over an extended period and experienced intense withdrawal and psychological symptoms after discontinuation.
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Consensus Report on XT Use in Practice

Read the full report
Figure: Graphic promoting Consensus Report on Xanomeline-Trospium; colorful net design shown with JCP logo in lower left.

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